DNAZEN: Enhanced Gene Sequence Representations via Mixed Granularities of Coding Units

Genome modeling conventionally treats gene sequence as a language, reflecting its structured motifs and long-range dependencies analogous to linguistic units and organization principles such as words and syntax. Recent studies utilize advanced neural networks, ranging from convolutional and recurrent models to Transformer-based models, to capture contextual information of gene sequence, with the primary goal of obtaining effective gene sequence representations and thus enhance the models' understanding of various running gene samples. However, these approaches often directly apply language modeling techniques to gene sequences and do not fully consider the intrinsic information organization in them, where they do not consider how units at different granularities contribute to representation. In this paper, we propose DNAZEN, an enhanced genomic representation framework designed to learn from various granularities in gene sequences, including small polymers and G-grams that are combinations of several contiguous polymers. Specifically, we extract the G-grams from large-scale genomic corpora through an unsupervised approach to construct the G-gram vocabulary, which is used to provide G-grams in the learning process of DNA sequences through dynamically matching from running gene samples. A Transformer-based G-gram encoder is also proposed and the matched G-grams are fed into it to compute their representations and integrated into the encoder for basic unit (E4BU), which is responsible for encoding small units and maintaining the learning and inference process. To further enhance the learning process, we propose whole G-gram masking to train DNAZEN, where the model largely favors the selection of each entire G-gram to mask rather than an ordinary masking mechanism performed on basic units. Experiments on benchmark datasets demonstrate the effectiveness of DNAZEN on various downstream tasks.

Multimodal Conditioned Diffusive Time Series Forecasting

Diffusion models achieve remarkable success in processing images and text, and have been extended to special domains such as time series forecasting (TSF). Existing diffusion-based approaches for TSF primarily focus on modeling single-modality numerical sequences, overlooking the rich multimodal information in time series data. To effectively leverage such information for prediction, we propose a multimodal conditioned diffusion model for TSF, namely, MCD-TSF, to jointly utilize timestamps and texts as extra guidance for time series modeling, especially for forecasting. Specifically, Timestamps are combined with time series to establish temporal and semantic correlations among different data points when aggregating information along the temporal dimension. Texts serve as supplementary descriptions of time series' history, and adaptively aligned with data points as well as dynamically controlled in a classifier-free manner. Extensive experiments on real-world benchmark datasets across eight domains demonstrate that the proposed MCD-TSF model achieves state-of-the-art performance.

ReMA: Learning to Meta-think for LLMs with Multi-Agent Reinforcement Learning

Recent research on Reasoning of Large Language Models (LLMs) has sought to further enhance their performance by integrating meta-thinking -- enabling models to monitor, evaluate, and control their reasoning processes for more adaptive and effective problem-solving. However, current single-agent work lacks a specialized design for acquiring meta-thinking, resulting in low efficacy. To address this challenge, we introduce Reinforced Meta-thinking Agents (ReMA), a novel framework that leverages Multi-Agent Reinforcement Learning (MARL) to elicit meta-thinking behaviors, encouraging LLMs to think about thinking. ReMA decouples the reasoning process into two hierarchical agents: a high-level meta-thinking agent responsible for generating strategic oversight and plans, and a low-level reasoning agent for detailed executions. Through iterative reinforcement learning with aligned objectives, these agents explore and learn collaboration, leading to improved generalization and robustness. Experimental results demonstrate that ReMA outperforms single-agent RL baselines on complex reasoning tasks, including competitive-level mathematical benchmarks and LLM-as-a-Judge benchmarks. Comprehensive ablation studies further illustrate the evolving dynamics of each distinct agent, providing valuable insights into how the meta-thinking reasoning process enhances the reasoning capabilities of LLMs.

From Target Tracking to Targeting Track -- Part II: Regularized Polynomial Trajectory Optimization

Target tracking entails the estimation of the evolution of the target state over time, namely the target trajectory. Different from the classical state space model, our series of studies, including this paper, model the collection of the target state as a stochastic process (SP) that is further decomposed into a deterministic part which represents the trend of the trajectory and a residual SP representing the residual fitting error. Subsequently, the tracking problem is formulated as a learning problem regarding the trajectory SP for which a key part is to estimate a trajectory FoT (T-FoT) best fitting the measurements in time series. For this purpose, we consider the polynomial T-FoT and address the regularized polynomial T-FoT optimization employing two distinct regularization strategies seeking trade-off between the accuracy and simplicity. One limits the order of the polynomial and then the best choice is determined by grid searching in a narrow, bounded range while the other adopts $\ell_0$ norm regularization for which the hybrid Newton solver is employed. Simulation results obtained in both single and multiple maneuvering target scenarios demonstrate the effectiveness of our approaches.

ThinkBench: Dynamic Out-of-Distribution Evaluation for Robust LLM Reasoning

Evaluating large language models (LLMs) poses significant challenges, particularly due to issues of data contamination and the leakage of correct answers. To address these challenges, we introduce ThinkBench, a novel evaluation framework designed to evaluate LLMs' reasoning capability robustly. ThinkBench proposes a dynamic data generation method for constructing out-of-distribution (OOD) datasets and offers an OOD dataset that contains 2,912 samples drawn from reasoning tasks. ThinkBench unifies the evaluation of reasoning models and non-reasoning models. We evaluate 16 LLMs and 4 PRMs under identical experimental conditions and show that most of the LLMs' performance are far from robust and they face a certain level of data leakage. By dynamically generating OOD datasets, ThinkBench effectively provides a reliable evaluation of LLMs and reduces the impact of data contamination.

FIND: Fine-grained Information Density Guided Adaptive Retrieval-Augmented Generation for Disease Diagnosis

Retrieval-Augmented Large Language Models (LLMs), which integrate external knowledge into LLMs, have shown remarkable performance in various medical domains, including clinical diagnosis. However, existing RAG methods struggle to effectively assess task difficulty to make retrieval decisions, thereby failing to meet the clinical requirements for balancing efficiency and accuracy. So in this paper, we propose FIND (\textbf{F}ine-grained \textbf{In}formation \textbf{D}ensity Guided Adaptive RAG), a novel framework that improves the reliability of RAG in disease diagnosis scenarios. FIND incorporates a fine-grained adaptive control module to determine whether retrieval is necessary based on the information density of the input. By optimizing the retrieval process and implementing a knowledge filtering module, FIND ensures that the retrieval is better suited to clinical scenarios. Experiments on three Chinese electronic medical record datasets demonstrate that FIND significantly outperforms various baseline methods, highlighting its effectiveness in clinical diagnosis tasks.

OpenR: An Open Source Framework for Advanced Reasoning with Large Language Models

In this technical report, we introduce OpenR, an open-source framework designed to integrate key components for enhancing the reasoning capabilities of large language models (LLMs). OpenR unifies data acquisition, reinforcement learning training (both online and offline), and non-autoregressive decoding into a cohesive software platform. Our goal is to establish an open-source platform and community to accelerate the development of LLM reasoning. Inspired by the success of OpenAI's o1 model, which demonstrated improved reasoning abilities through step-by-step reasoning and reinforcement learning, OpenR integrates test-time compute, reinforcement learning, and process supervision to improve reasoning in LLMs. Our work is the first to provide an open-source framework that explores the core techniques of OpenAI's o1 model with reinforcement learning, achieving advanced reasoning capabilities beyond traditional autoregressive methods. We demonstrate the efficacy of OpenR by evaluating it on the MATH dataset, utilising publicly available data and search methods. Our initial experiments confirm substantial gains, with relative improvements in reasoning and performance driven by test-time computation and reinforcement learning through process reward models. The OpenR framework, including code, models, and datasets, is accessible at https://openreasoner.github.io.

Efficient Reinforcement Learning with Large Language Model Priors

In sequential decision-making (SDM) tasks, methods like reinforcement learning (RL) and heuristic search have made notable advances in specific cases. However, they often require extensive exploration and face challenges in generalizing across diverse environments due to their limited grasp of the underlying decision dynamics. In contrast, large language models (LLMs) have recently emerged as powerful general-purpose tools, due to their capacity to maintain vast amounts of domain-specific knowledge. To harness this rich prior knowledge for efficiently solving complex SDM tasks, we propose treating LLMs as prior action distributions and integrating them into RL frameworks through Bayesian inference methods, making use of variational inference and direct posterior sampling. The proposed approaches facilitate the seamless incorporation of fixed LLM priors into both policy-based and value-based RL frameworks. Our experiments show that incorporating LLM-based action priors significantly reduces exploration and optimization complexity, substantially improving sample efficiency compared to traditional RL techniques, e.g., using LLM priors decreases the number of required samples by over 90% in offline learning scenarios.

Prototype based Masked Audio Model for Self-Supervised Learning of Sound Event Detection

A significant challenge in sound event detection (SED) is the effective utilization of unlabeled data, given the limited availability of labeled data due to high annotation costs. Semi-supervised algorithms rely on labeled data to learn from unlabeled data, and the performance is constrained by the quality and size of the former. In this paper, we introduce the Prototype based Masked Audio Model~(PMAM) algorithm for self-supervised representation learning in SED, to better exploit unlabeled data. Specifically, semantically rich frame-level pseudo labels are constructed from a Gaussian mixture model (GMM) based prototypical distribution modeling. These pseudo labels supervise the learning of a Transformer-based masked audio model, in which binary cross-entropy loss is employed instead of the widely used InfoNCE loss, to provide independent loss contributions from different prototypes, which is important in real scenarios in which multiple labels may apply to unsupervised data frames. A final stage of fine-tuning with just a small amount of labeled data yields a very high performing SED model. On like-for-like tests using the DESED task, our method achieves a PSDS1 score of 62.5\%, surpassing current state-of-the-art models and demonstrating the superiority of the proposed technique.

USTC-KXDIGIT System Description for ASVspoof5 Challenge

This paper describes the USTC-KXDIGIT system submitted to the ASVspoof5 Challenge for Track 1 (speech deepfake detection) and Track 2 (spoofing-robust automatic speaker verification, SASV). Track 1 showcases a diverse range of technical qualities from potential processing algorithms and includes both open and closed conditions. For these conditions, our system consists of a cascade of a frontend feature extractor and a back-end classifier. We focus on extensive embedding engineering and enhancing the generalization of the back-end classifier model. Specifically, the embedding engineering is based on hand-crafted features and speech representations from a self-supervised model, used for closed and open conditions, respectively. To detect spoof attacks under various adversarial conditions, we trained multiple systems on an augmented training set. Additionally, we used voice conversion technology to synthesize fake audio from genuine audio in the training set to enrich the synthesis algorithms. To leverage the complementary information learned by different model architectures, we employed activation ensemble and fused scores from different systems to obtain the final decision score for spoof detection. During the evaluation phase, the proposed methods achieved 0.3948 minDCF and 14.33% EER in the close condition, and 0.0750 minDCF and 2.59% EER in the open condition, demonstrating the robustness of our submitted systems under adversarial conditions. In Track 2, we continued using the CM system from Track 1 and fused it with a CNN-based ASV system. This approach achieved 0.2814 min-aDCF in the closed condition and 0.0756 min-aDCF in the open condition, showcasing superior performance in the SASV system.